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Axioimager.Z2 With An Apotome.2 Structured Illumination Epifluorescent Microscope, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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epifluorescence microscope using structured illumination hardware and deconvolution software  (Carl Zeiss)
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Epifluorescence Microscope Using Structured Illumination Hardware And Deconvolution Software, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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apotome epifluorescence microscope with structured illumination hardware and deconvolution software  (Carl Zeiss)
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a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in <t>deconvolution</t> of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.
Apotome Epifluorescence Microscope With Structured Illumination Hardware And Deconvolution Software, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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epifluorescence images using zeiss axio imager.m2 upright microscope equipped with an apotome.2 structured illumination modules  (Carl Zeiss)
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Carl Zeiss epifluorescence images using zeiss axio imager.m2 upright microscope equipped with an apotome.2 structured illumination modules
a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in <t>deconvolution</t> of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.
Epifluorescence Images Using Zeiss Axio Imager.M2 Upright Microscope Equipped With An Apotome.2 Structured Illumination Modules, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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axio observer epifluorescence microscope with apotome structured illumination  (Carl Zeiss)
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Carl Zeiss axio observer epifluorescence microscope with apotome structured illumination
a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in <t>deconvolution</t> of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.
Axio Observer Epifluorescence Microscope With Apotome Structured Illumination, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/axio observer epifluorescence microscope with apotome structured illumination/product/Carl Zeiss
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epifluorescent microscope with structured illumination zeiss axio imager.z2 with apotome.2  (Carl Zeiss)
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Carl Zeiss epifluorescent microscope with structured illumination zeiss axio imager.z2 with apotome.2
a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in <t>deconvolution</t> of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.
Epifluorescent Microscope With Structured Illumination Zeiss Axio Imager.Z2 With Apotome.2, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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epifluorescence microscope with structured illumination zeiss axioobserver z1 with apotome 2  (Carl Zeiss)
90
Carl Zeiss epifluorescence microscope with structured illumination zeiss axioobserver z1 with apotome 2
a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in <t>deconvolution</t> of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.
Epifluorescence Microscope With Structured Illumination Zeiss Axioobserver Z1 With Apotome 2, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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apotome structural illumination epifluorescence microscope with a 63× oil immersion objective  (Carl Zeiss)
90
Carl Zeiss apotome structural illumination epifluorescence microscope with a 63× oil immersion objective
a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in <t>deconvolution</t> of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.
Apotome Structural Illumination Epifluorescence Microscope With A 63× Oil Immersion Objective, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/apotome structural illumination epifluorescence microscope with a 63× oil immersion objective/product/Carl Zeiss
Average 90 stars, based on 1 article reviews
apotome structural illumination epifluorescence microscope with a 63× oil immersion objective - by Bioz Stars, 2026-05
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Image Search Results


a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in deconvolution of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.

Journal: bioRxiv

Article Title: Lesion-remote astrocytes govern microglia-mediated white matter repair

doi: 10.1101/2024.03.15.585251

Figure Lengend Snippet: a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in deconvolution of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.

Article Snippet: Images of tissue sections used for quantitative analyses were collected using an Apotome epifluorescence microscope with structured illumination hardware and deconvolution software (Zeiss).

Techniques: Comparison, RNA Sequencing, Gene Expression, Expressing